Adalat LA 30mg Tablets 30’s

Description
Adalat LA contains nifedipine, which belongs to a group of medicines called calcium antagonists. Adalat LA is used to treat high blood pressure or angina (chest pain).For high blood pressure: Adalat LA works by relaxing and expanding the blood vessels.This makes the blood flow more easily and lowers blood pressure.Lower blood pressure reduces the strain on your heart.For angina: Adalat LA works by relaxing and expanding the arteries supplying the heart. This allows more blood and oxygen to reach the heart and decreases the strain on it. Your angina attacks will be less severe and less frequent if there is less strain on the heart.
Qualitative and quantitative composition:
Each prolonged-release tablet contains 30 mg nifedipine. Each tablet contains a 10% overage of nifedipine to deliver the label claim.
Therapeutic indications:
For the treatment of all grades of hypertension. For the prophylaxis of chronic stable angina pectoris either as monotherapy or in combination with a beta-blocker.
How to use
Posology: In mild to moderate hypertension, the recommended initial dose is one 20 mg tablet once-daily. In severe hypertension, the recommended initial dose is one 30 mg tablet once-daily. If necessary, the dosage can be increased according to individual requirements up to a maximum of 90 mg once-daily. For the prophylaxis of angina pectoris, the recommended initial dose is one 30 mg tablet once-daily. The dosage can be increased according to individual requirements up to a maximum of 90 mg once-daily. Patients in whom hypertension or anginal symptoms are controlled on Adalat capsules or Adalat retard may be safely switched to Adalat LA. Prophylactic anti-anginal efficacy is maintained when patients are switched from other calcium antagonists such as diltiazem or verapamil to Adalat LA. Patients switched from other calcium antagonists should initiate therapy at the recommended initial dose of 30 mg Adalat LA once-daily. Subsequent titration to a higher dose may be initiated as warranted clinically. Co-administration with CYP 3A4 inhibitors or CYP 3A4 inducers may result in the recommendation to adapt the nifedipine dose or not to use nifedipine at all.
Method of administration: Oral use.
The tablets should be swallowed whole with a glass of water, either with or without food. The tablets should be taken at approximately 24-hour intervals, i.e. at the same time each day, preferably during the morning. Adalat LA tablets must be swallowed whole; under no circumstances should they be bitten, chewed or broken up. Adalat LA should not be taken with grapefruit juice.
Precautions
Contraindications: -Adalat LA should not be administered to patients with known hypersensitivity to the active substance, or to other dihydropyridines because of the theoretical risk of cross-reactivity, or to any of the excipients listed. -Adalat LA should not be used in cases of cardiogenic shock, clinically significant aortic stenosis, unstable angina, or during or within one month of a myocardial infarction. -Adalat LA should not be used for the treatment of acute attacks of angina. The safety of Adalat LA in malignant hypertension has not been established. Adalat LA should not be used for secondary prevention of myocardial infarction. Owing to the duration of action of the formulation, Adalat LA should not be administered to patients with hepatic impairment. -Adalat LA should not be administered to patients with a history of gastro-intestinal obstruction, oesophageal obstruction, or any degree of decreased lumen diameter of the gastro-intestinal tract. -Adalat LA must not be used in patients with a Kock pouch (ileostomy after proctocolectomy). Adalat LA is contra-indicated in patients with inflammatory bowel disease or Crohn’s disease. Adalat LA should not be administered concomitantly with rifampicin since effective plasma levels of nifedipine may not be achieved owing to enzyme induction.

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